Would you use SBRT to a localized low grade neuroendocrine carcinoma in the head of pancreas in a patient with high surgical risk?

Yes, this is a reasonable approach that has been reported previously in the literature for pancreatic neuroendocrine neoplasms (see: Myrehaug et al., PMID 32185093; Duran et al., HPB 2021 [abstract]; a single case included in Goyal et al., PMID 21937061 as well). SBRT in this setting often provides ...

Yes.

There is little published data in this area to my knowledge, with most studies being small single institution series and some with varying histologies. That being said, if the decision is made to pursue local therapy rather than observation (due to size, growth) and the patient is medically inoperab...