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Would you use single agent adjuvant HER2 directed therapy for patients with low risk HER2+ breast cancer who are not candidates for chemotherapy?

1 Answer
Mednet MemberInvited Expert
Medical Oncology · University of North Carolina
Answered on

There are no data regarding single agent trastuzumab as adjuvant therapy, and the existing studies (FinHER, SOLD) suggest that much of the benefit occurs during the chemotherapy phase. The "after chemo" efforts (HERA, N9831) appear inferior. So I would try to incorporate the chemotherapy component, the least aggressive being the APT regimen (12 weeks paclitaxel + trastuzumab then complete the trastuzumab part, Tolaney NEJM 2016), which was really tested in stage I mostly HR+ HER2+ disease so nor...

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