Would you utilize splenic radiation for patients with non-myeloid malignancy and splenomegaly in the setting of platelet sequestration, which is limiting cytotoxic systemic therapy options?

More specifically, in a patient with prior bilateral liver radioembolization leading to radiation-induced liver disease and associated portal hypertension, would radiation to the spleen improve low platelets in this setting?

Answer from: Radiation Oncologist at Community Practice

I am not sure if I understand your question correctly. However, if splenomegaly is not associated with a) lymphoma infiltration of the spleen or b) ectopic hematopoiesis in the spleen, then spleen irradiation will not help.

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Would you utilize splenic radiation for patients with non-myeloid malignancy and splenomegaly in the setting of platelet sequestration, which is limiting cytotoxic systemic therapy options?

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