If a patient with initially borderline resectable pancreatic cancer receives neoadjuvant CHT followed by CRT and is ultimately deemed unresectable, do you consider an RT boost?  

I am careful not to give low-dose preop radiation to someone who might not have surgery. We have done a prospective trial to show that surgery is safe after an ablative dose (Reyngold et al., IJROBP, 2025). There is no published evidence that a boost after a two-month break will be helpful or safe, ...