Would you utilize splenic radiation for patients with non-myeloid malignancy and splenomegaly in the setting of platelet sequestration, which is limiting cytotoxic systemic therapy options?

I am not sure if I understand your question correctly. However, if splenomegaly is not associated with a) lymphoma infiltration of the spleen or b) ectopic hematopoiesis in the spleen, then spleen irradiation will not help.