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Are pre-menopausal women on tamoxifen at risk for endometrial cancer?
3 Answers
Mednet Member
Medical Oncology · University of Michigan Medical School
Analysis of endometrial cancer rates in the NSABP P1 trial in women under age 50, demonstrated a relative risk of 1.42 (0.55-3.81) for tamoxifen that was not statistically significant. Per 1000 women, the rates were 0.82 for placebo and 1.16 for tamoxifen. (Fisher et al., PMID 16288118)
Mednet Member
Medical Oncology · Valley Med Onc
The ACOG position is that Tamoxifen does not increase the risk of uterine cancer in premenopausal women: