Are there any types of sarcomas that you use induction and/or concurrent chemotherapy with radiation prior to surgery?

Neoadjuvant chemotherapy is controversial in extremity/trunk STS.

Generally speaking, grade 2/3 tumors that are ≥5 cm are at high-risk for distant recurrence despite ~90% local control. For these patients, you can consider neoadjuvant chemoRT.

When using neoadjuvant chemoRT, the more common approach ...

We sometimes now give concurrent chemoxrt for limb sarcoma as was done on ARST1321.

ARST1321 was a phase 3 clinical trial in which patients with soft tissue sarcoma received preoperative doxorubicin+ifosfamide and concurrent radiation with or without concurrent pazopanib. Postoperatively, study part...