Are there circumstances where you would recommend every 6 week dosing schedule for pembrolizumab monotherapy?
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3 Answers
Mednet Member
Medical Oncology · Cleveland Clinic
FDA approval for q 6 week dosing of pembrolizumab is awaited but has yet to occur; this would represent a welcome change for our patients, as just happened with the recent approval of q 4 week dosing of atezolizumab.
Without FDA approval we are not using pembrolizumab 6 week dosing at this time, and...
Mednet Member
Medical Oncology · Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
Based on exposure-response evaluation using modeling and simulation data (ASCO 2018), I feel comfortable spacing out treatment to every 6 weeks in the current COVID crisis, particularly in elderly patients who have been on the agent for a while with excellent response and minimal disease burden.
How...
Mednet Member
Medical Oncology · Karmanos Cancer Institute
I still favor 3-weekly pembrolizumab in the following situations:
1. During the induction of chemo-immunotherapy.
2. In maintenance phase with pemetrexed-pembrolizumab combination for adenocarcinoma.
3. When there is a concern of toxicity and I need to follow closely.
6-weekly 400 mg pembrolizumab...