Hematology

Bone Marrow Failure

Questions discussed in this category

For transplant-ineligible aplastic anemia planned for immunosuppression, how do you approach duration and tapering of cyclosporine and eltrombopag?

How do you decide between 6 vs 12 months of therapy, or longer? And how often are you changing doses of these drugs when tapering?

1 Answer available

In a pregnant patient with PNH without aplastic anemia who has residual hemolysis while on ravulizumab and on prophylactic LMWH, what else can be done to reduce thrombotic risk and improve maternofetal outcomes?

Hemoglobin 9-10 with high LDH and reticulocyte count. Follows with MFM as well. Would you consider increasing ravulizumab frequency or switching to e...

1 Answer available

How would you manage aplastic anemia refractory to multiple agents?

Treated initially with hATG/CNI/TPO, but then relapsed. Subsequently treated with cyclosporine, danazol, ESA, and alemtuzumab, but still with pancytop...

1 Answer available

In pure red cell aplasia, does peripheral blood-positive IgG for parvovirus have significance if persistently positive on retesting, but IgM and PCR are negative?

The patient has a recurrence of the disease despite tapering prednisone and cyclosporine. Bone marrow exams x2 without MDS. Testing for all other caus...

1 Answer available

How do you decide between HSCT and immunosuppressive therapy for treating hepatitis associated aplastic anemia?

1 Answer available

How would you work up a mildly neutropenic patient (ANC >800) with family history of neutropenia and personal history of occasional mouth sore?

What are indications to order gene mutation studies (e.g. ELANE) and how would it help the patient?

1 Answer available

When would you consider transplant for a patient with a bone marrow failure syndrome (FA, DC, etc.)?

2 Answers available

How would you manage a patient with severe aplastic anemia and a large PNH clone?

1 Answer available

Would you stop current immunosuppressive therapy or delay starting immunosuppressive therapy in a patient with aplastic anemia who has been infected with COVID-19?

2 Answers available