Primary Care

Allopurinol

Questions discussed in this category

Are there patients with gout in whom you would choose febuxostat first line over allopurinol for urate lowering therapy?

This question is part of a collaboration with RheumMadness and is specifically in reference to: Allopurinol vs. Febuxostat

1 Answer available

How do you approach urate-lowering therapy in patients with advanced chronic kidney disease?

What doses of allopurinol do you use, and how frequently do you titrate the dose?

1 Answer available

How do you approach transaminase elevations with use of allopurinol in gout?

Do you rechallenge with lower dose? What is your tolerance for mild persistent transaminitis?

1 Answer available

Do you recommend allopurinol desensitization in gout patients who develop a rash on allopurinol therapy?

2 Answers available

Do you screen for HLA-B*5801 prior to starting allopurinol in patients of backgrounds other than Asian or African-American?

Specifically in patients of Vietnamese background? An association has been shown between HLA-B*5801 and the risk of allopurinol hypersensitivity react...

1 Answer available

Is it ever appropriate to initiate a higher initial dose of allopurinol (such as 300mg daily) than is typically recommended in gout patients at low risk of allopurinol hypersensitivity syndrome and severe hyperuricemia?

2 Answers available

Papers discussed in this category

The New England journal of medicine, 2018-03-29

Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout.

Lancet, 2020 Nov 09

Long-term cardiovascular safety of febuxostat compared with allopurinol in patients with gout (FAST): a multicentre, prospective, randomised, open-label, non-inferiority trial.

Arthritis Care Res (Hoboken), 2020 May 11

2020 American College of Rheumatology Guideline for the Management of Gout.

Primary Care

Allopurinol

Questions discussed in this category

Papers discussed in this category

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