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Pulmonology

Sarcoidosis   

Questions discussed in this category

What serologic biomarkers do you send to assess for sarcoidosis at baseline and/or during flares, in patients where it may correlate with disease activity?
Specifically, do you check for any of these: ACE, Vitamin D 1,25, serum lysozyme, soluble IL2 or Adenosine deaminase levels?
1 Answer available
How do you approach management of adult patients with CVID and sarcoid-like syndrome?
1 Answer available
How do you approach medication management in biopsy-proven pulmonary sarcoidosis with disease stable for over 2 years on hydroxychloroquine and low dose prednisone?
Do you discontinue HCQ?
1 Answer available
Do you consider skin involvement associated with tattoos to be a marker of disease activity and an indication to start treatment in a patient with sarcoidosis?
1 Answer available
How do you approach treating and monitoring sarcoidosis manifested by maxillary bone/teeth loss without other symptoms?
3 Answers available
How do you workup patients with neuropathy suspected to be secondary to sarcoid?
Is a biopsy or EMG helpful in confirming the etiology? What is the best treatment for sarcoid neuropathy?
1 Answer available
How would you manage asymptomatic osseous sarcoidosis of the lumbar spine without any other systemic involvement?
Would you use with DMARDs/biologics or monitor?
1 Answer available
What is your approach for disease activity monitoring in patients with sarcoidosis?
1 Answer available
Do you consider pulmonary hypertension related to sarcoidosis to be an indication to start steroids?
Do you use biomarkers or PET scanning to stratify patients who may benefit most from therapy?
1 Answer available
Is it safe to combine mycophenolate and adalimumab for management of pulmonary sarcoidosis in a patient that could not tolerate methotrexate?
3 Answers available
What is your approach to monitoring patients with cardiac sarcoid while tapering immunosuppression?
Do you obtain serial cardiac PET scans?
1 Answer available
What is your approach to a patient who has a cardiac PET scan suggestive of sarcoid but no other supporting evidence of a diagnosis of sarcoid?
Do you typically push for myocardial biopsy in this case? 
1 Answer available
How do you approach treating mild hypercalcemia in patients with sarcoidosis?
1 Answer available
Do you continue methotrexate while starting TNFi therapy in patients with refractory pulmonary sarcoidosis?
3 Answers available
What is your approach to therapy for pulmonary sarcoidosis resistant to methotrexate?
1 Answer available
Is there a role for the use of inhaled corticosteroids in patients with pulmonary sarcoidosis who have stage II or III disease with abnormal lung function but only mild respiratory symptoms?
1 Answer available
Do you utilize soluble IL-2 receptor or ACE levels as serum biomarkers to monitor disease activity in pulmonary sarcoidosis?
1 Answer available
How do you treat patients with sarcoid who have persistent symptoms after an initial 6 week course of corticosteroids?
3 Answers available
How do you treat multisystem sarcoidosis refractory to methotrexate, humira, and remicade?
2 Answers available
What steroid sparing agent do you use for treatment of cardiac sarcoidosis?
Does the type of cardiac involvement impact this choice?
2 Answers available
How do you manage calcium and vitamin D supplementation in patients with sarcoidosis on chronic steroids?
1 Answer available


Papers discussed in this category

Semin Arthritis Rheum, 2020 Jun
TNF-alpha inhibition for the treatment of cardiac sarcoidosis.
Intern Med, 2014 Dec 01
Treatment with methotrexate and low-dose corticosteroids in sarcoidosis patients with cardiac lesions.
J Am Heart Assoc, 2019 Sep 06
Long-Term Corticosteroid-Sparing Immunosuppression for Cardiac Sarcoidosis.
Clin Rheumatol, 2007 Mar 30
Cardiac sarcoidosis responding to monotherapy with infliximab.
Respir Med, 2012 Apr 09
The treatment of pulmonary sarcoidosis.
Am J Respir Crit Care Med,
Statement on sarcoidosis. Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999.
The European respiratory journal, 2014-11
Safety and efficacy of ustekinumab or golimumab in patients with chronic sarcoidosis.
Clin Exp Rheumatol, 2019 Nov 20
Use of third-line therapies in advanced sarcoidosis.
N Engl J Med,
Tofacitinib Treatment and Molecular Analysis of Cutaneous Sarcoidosis.
Lung, 2021 Apr 07
Tofacitinib as a Steroid-Sparing Therapy in Pulmonary Sarcoidosis, an Open-Label Prospective Proof-of-Concept Study.
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG, 2002-10
Use of fluticasone in acute symptomatic pulmonary sarcoidosis.
Eur Respir J,
Randomized trial of inhaled fluticasone propionate in chronic stable pulmonary sarcoidosis: a pilot study.
Eur Respir J,
Inhaled budesonide in pulmonary sarcoidosis: a double-blind, placebo-controlled study. Dutch Study Group on Pulmonary Sarcoidosis.
J Intern Med,
No effect of high-dose inhaled steroids in pulmonary sarcoidosis: a double-blind, placebo-controlled study.
Drugs,
Incidence, Prevention and Management of Anti-Drug Antibodies Against Therapeutic Antibodies in Inflammatory Bowel Disease: A Practical Overview.
Eur Respir J, 2021 Dec 16
ERS clinical practice guidelines on treatment of sarcoidosis.
AACE Clin Case Rep, 2020 Aug 06
METHOTREXATE TREATMENT FOR SARCOIDOSIS-INDUCED HYPERCALCEMIA.
Am J Med, 1987 Jun
Hydroxychloroquine treatment of hypercalcemia in a patient with sarcoidosis undergoing hemodialysis.
Sarcoidosis Vasc Diffuse Lung Dis, 2012 Mar
Hypercalcemia from sarcoidosis successfully treated with infliximab.
Arch Osteoporos, 2017 Jul 19
Glucocorticoid sparing effect of zoledronic acid in sarcoid hypercalcemia.
BMJ Case Rep, 2022 Jul 08
Hungry bone syndrome like presentation following single-dose denosumab for hypercalcaemia secondary to sarcoidosis with IgA nephropathy.
Arthritis Res Ther, 2014 Mar 24
Bone fragility in sarcoidosis and relationships with calcium metabolism disorders: a cross sectional study on 142 patients.
Arthritis & rheumatology (Hoboken, N.J.), 2015-05
Clinical utility of random anti-tumor necrosis factor drug-level testing and measurement of antidrug antibodies on the long-term treatment response in rheumatoid arthritis.
International journal of rheumatic diseases, 2014-02
Neurosarcoidosis mimicking multiple sclerosis successfully treated with methotrexate and adalimumab.
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG, 2014-04-18
Efficacy Results of a 52-week Trial of Adalimumab in the Treatment of Refractory Sarcoidosis.
Clinical nuclear medicine, 2016-05
FDG PET/CT Evidence of Effective Treatment of Cardiac Sarcoidosis With Adalimumab.
J Investig Med High Impact Case Rep, 2021 Jan-Dec
Pituitary Sarcoidosis in a Pediatric Patient Successfully Treated With Adalimumab and Methotrexate.
Clinical therapeutics, 2018 Feb
Methotrexate Dose in Patients With Early Rheumatoid Arthritis Impacts Methotrexate Polyglutamate Pharmacokinetics, Adalimumab Pharmacokinetics, and Efficacy: Pharmacokinetic and Exposure-response Analysis of the CONCERTO Trial.
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG, 2014-04-18
The WASOG Sarcoidosis Organ Assessment Instrument: An update of a previous clinical tool.
Heart rhythm, 2014-07
HRS expert consensus statement on the diagnosis and management of arrhythmias associated with cardiac sarcoidosis.
Circulation journal : official journal of the Japanese Circulation Society, 2019 Oct 09
JCS 2016 Guideline on Diagnosis and Treatment of Cardiac Sarcoidosis　- Digest Version.
Arrhythmia & electrophysiology review, 2020 Dec
Management of Cardiac Sarcoidosis in 2020.
JAMA neurology, 2018-12-01
Definition and Consensus Diagnostic Criteria for Neurosarcoidosis: From the Neurosarcoidosis Consortium Consensus Group.
Journal of neuroimmunology, 2022 Apr 09
Peripheral neuropathy in sarcoidosis.
Expert review of respiratory medicine, 2023 Jun 23
Diagnostic accuracy of interleukin-2 receptor in sarcoidosis: a systematic review and meta-analysis.
Current opinion in pulmonary medicine, 2013 Sep
Common variable immunodeficiency-associated granulomatous and interstitial lung disease.

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