Anaphylaxis

Questions discussed in this category

Would rhapsido be beneficial in patients with MCAS who experience anaphylaxis?

1 Answer available

What do you consider an appropriate observation period following resolution of anaphylaxis signs and symptoms given the risk of biphasic reactions?

1 Answer available

Do you switch from 0.15 mg to 0.3 mg epinephrine at 55lbs or 66lbs?

Seems like AAP and AAAI support switch to 0.3 woolen at 55lbs and FDA and Woolen package insert at 66lbs. Any thoughts on when to switch?

1 Answer available

In a patient with anaphylaxis and loss of consciousness from stinging insect, suspected to be yellow jacket, the sIgE was significantly positive to all vespids, but honeybee and paper wasp were only 0.44, would you evaluate further with skin testing to wasp and decide on including wasp in treatment based on skin testing being positive or include it with just the low IgE level?

2 Answers available

What functional assays do you recommend to determine if MGRPRX2 receptor activation has led to a non-IgE mediated anaphylaxis?

1 Answer available

Do you continue to check tryptase levels in your patients with idiopathic anaphylaxis despite normal levels >5 on repeated checks?

1 Answer available

Papers discussed in this category

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2023 Dec 18

Anaphylaxis: A 2023 practice parameter update.

The Journal of clinical investigation, 2020 Sep 01

Bruton's tyrosine kinase inhibition effectively protects against human IgE-mediated anaphylaxis.

The Journal of allergy and clinical immunology, 2025 Jul 17

The Bruton tyrosine kinase inhibitor acalabrutinib aborts ongoing acute food-induced anaphylactic reactions in humanized mice.

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