Dermatology
Clinical insights on skin conditions, dermatologic procedures, and treatment approaches from practicing dermatologists.
Recent Discussions
What do you view as the optimal use and timing of cemiplimab in high risk CSCC?
Increasingly, neoadjuvant cemiplimab has become our preferred approach for many patients with resectable high-risk CSCC, and this is consistent with what several high-volume centers are now doing. The high pathologic response rates, durable recurrence-free survival in responders, and meaningful surg...
Would you continue cemiplimab adjuvantly, following resection of initially unresectable cutaneous squamous cell carcinoma treated with downstaging immunotherapy?
This is a challenging question because, as you know, we have no randomized data to address it. I generally do not continue immune checkpoint therapy after resection of SCC skin. However, given the adjuvant data in melanoma and the high efficacy of anti-PD1 in skin SCC, I do think it is reasonable to...
What are your favorite modalities for preventing hypergranulation tissue?
Although exuberant granulation tissue is not totally preventable nor predictable, persistent inflammatory impetus, such as from hairs embedded in a surgical closure, or spitting suture reactions, can stimulate excess granulation tissue. Careful avoidance of trapped hairs as well as burying absorbabl...
How do you treat gram-negative folliculitis in a transplant patient on sirolimus who cannot use isotretinoin due to drug interactions?
The most critical issue with these infections in the immunocompromised host is the correct identification of the organism and its sensitivities to allow appropriate selection and course of antibiotics. Because the infection is deep in the hair follicle and the patient will shave the area, there is a...
Is keratosis follicularis (Darier disease) a contraindication to the receipt of PMRT?
Thanks for this interesting question. It prompted me to do a bit of literature search and think about how I'd approach this case.For a postmenopausal patient with ER-negative, PR-negative, HER2-negative (triple-negative) pT2N0(sn) breast cancer and unresectable positive surgical margins after mastec...
How have you applied the findings of this trial to your current approach to prescribing rituximab for pemphigus patients?
For the MMF vs MMF + Rituximab trial, the patients received two courses of Rituximab six months apart. The B cells don’t start to recover until about six months after the infusions. The data shows more patients in the rituximab group achieved sustained CRoff pred for 15 weeks or more relative to MMF...
Would you give adjuvant radiation after complete resection of a small primary cutaneous follicular lymphoma of the scalp?
Not a lot of data, but here goes. First, one has to go back decades in the literature to find series of patients with lymphoma rx'd with surgical resection alone. In general addition of RT improved outcome even when ostensibly resected with neg margins. With today's technology risk of additional RT ...
Would you stop bimekizumab in a patient who has severe psoriasis and has responded well to this therapy but is found to have newly diagnosed cirrhosis?
I'd want to know if there was some other cause for the cirrhosis. If there were, I would not stop the bimekizumab. If there was not a clear, obvious cause, I'd want the patient evaluated by a hepatologist. If the hepatologist could find some other reason for the cirrhosis, it might not be necessary ...
How do you manage recurrent scabies in both a patient and their partner when standard therapy fails?
I would recommend 2 weekly treatments with oral ivermectin and topical permethrin. It is also very important to discuss control of fomite exposure as well as possible occult sources e.g., relatives and close friends.
How do you handle hypogammaglobulinemia detected in patients prior to maintenance rituximab infusion?
That is a good question. Adding on to Dr. @Dr. First Last's response, rituximab has been shown to cause hypogammaglobulinemia that can persist or worsen with ongoing therapy. In a study published by Barmettler and colleagues, 133 patients out of a cohort of 8633 patients had serum IgG levels checked...