General Internal Medicine

Systemic autoimmune diseases

Questions discussed in this category

What is your approach to managing pyoderma gangrenosum recalcitrant to oral steroids?

When do you switch to steroid-sparing medications? What steroid-sparing therapies do you prefer?

8 Answers available

How would you approach management of a patient with rapidly progressive systemic sclerosis with worsening skin disease, myositis, arthritis, dysphagia and failure to thrive developing within 6 months?

The patient is a young African American female of reproductive age with positive Fibrillarin antibody and nucleolar antibody. No ILD.

1 Answer available

How would you interpret a positive single specific markers like SSA or SSB in setting of working up an connective tissue disease, especially when ANA is negative?

1 Answer available

Would you avoid combining JAK inhibitors with IVIG given the risk of thromboembolism?

4 Answers available

How do you recommend tapering IVIG in patients whose inflammatory myositis has achieved remission?

4 Answers available

How long can you treat dermatomyositis with IVIG?

3 Answers available

How do you approach treating patients with lupus profundus?

Do you typically start the patient on hydroxychloroquine? What work-up do you perform?

1 Answer available

Do you screen for interstitial lung disease in patients with newly diagnosed polymyositis or dermatomyositis in the absence of respiratory symptoms?

3 Answers available

What is the negative predictive value of a negative extended myositis panel in dermatomyositis patients?

2 Answers available

Papers discussed in this category

The British journal of dermatology, 2019-11

Utilization patterns and performance of commercial myositis autoantibody panels in routine clinical practice.

Frontiers in immunology, 2019

Comparison of Three Immunoassays for the Detection of Myositis Specific Antibodies.

J Am Acad Dermatol, 2020 Sep 04

Accuracy of commercial panels to evaluate myositis autoantibodies: A single-institution perspective.

Rheumatology (Oxford),

The reliability of immunoassays to detect autoantibodies in patients with myositis is dependent on autoantibody specificity.

Ann Afr Med, 2020 Jul-Sep

Refractory lupus panniculitis treated successfully with rituximab: Two cases.

Arch Dermatol, 2006 Mar

Lupus erythematosus profundus successfully treated with dapsone: review of the literature.

Clin Rev Allergy Immunol, 2010 Apr

Intravenous immunoglobulin in lupus panniculitis.

Lupus, 2020 Mar 19

Successful treatment of refractory lupus erythematosus profundus with the interleukin-6 antagonist tocilizumab: a case report.

N Engl J Med, 2022 Oct 06

Trial of Intravenous Immune Globulin in Dermatomyositis.

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