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Mast Cell Disorders   

Questions discussed in this category


Do you recommend patients try antihistamines such as oral ketotifen that are not approved in the US but are approved in the EU for MCAS if currently available formulations have not been effective?
1 Answer available

Does a patient with known systemic mastocytosis need a bone biopsy of lytic vertebral lesions to rule out other etiologies?
1 Answer available

Is there any role for immunosuppressive/immunomodulatory therapy used off label for mast cell activation syndrome besides omalizumab?
1 Answer available

Are you requiring markers other than LTE4 to be elevated to diagnose MCAS?
There has been new data to suggest LTE4 is not the best urinary marker of mast cell activation, so are you requiring other markers to be elevated to d...
1 Answer available

Do you favor 24 hour urinary metabolites over random urine collection when screening for MCAS?
1 Answer available

Do you diagnose MCAS if a patient is concurrently on drugs known to cause non-specific mast cell degranulation?
1 Answer available
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Papers discussed in this category


The journal of allergy and clinical immunology. In practice, 2022 Mar 26
Nontryptase Urinary and Hematologic Biomarkers of Mast Cell Expansion and Mast Cell Activation: Status 2022.

The journal of allergy and clinical immunology. In practice, 2022 Mar 25
Personalized Management Strategies in Mast Cell Disorders: ECNM-AIM User's Guide for Daily Clinical Practice.

Related Topics

  • Allergy & Immunology
  • Hematology
  • General Internal Medicine
  • Primary Care
  • Gastroenterology
  • Gastrointestinal Functional & Motility Disorders
  • General Gastroenterology
  • Rheumatology
  • Mastocytosis

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