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Allergy & Immunology • Mast Cell Disorders
Should a patient who has hereditary alpha tryptasemia and has experienced multiple anaphylactoid reactions be tested for a venom allergy and started on VIT if positive?
He cannot recall if he has been stung but if he did, it preceded his diagnosis and onset of symptoms, and he had no reaction. He has never been stung since his HaT symptoms started.
Answer from: at Academic Institution
No. Only individuals with a history of anaphylaxis following a Hymenoptera insect sting should be offered venom-specific IgE testing and/or skin testing. There are rare exceptions, including beekeepers with frequent large local reactions. The person from the question stem does not have a history of ...
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Answer from: at Academic Institution
HAT carriers *are* enriched in individuals with severe Hymenoptera anaphylaxis, and the Chollet and Akin paper, while important, is insufficiently powered to detect the presence or absence of clinical associations in HATS carriers vs controls in an unselected population.