Medical Oncology

Onconephrology

Questions discussed in this category

Do you have a higher threshold regarding when to hold bevacizumab for proteinuria in patients who had known baseline proteinuria from diabetic nephropathy?

2 Answers available

Would you recommend initiating a SGLT2i for proteinuria secondary to bevacizumab in a patient who has a sub-optimal response to an ACEi or ARB?

2 Answers available

What is the management strategy for patients who develop AKI and nephrotic range proteinuria secondary to biopsy proven FSGS during immune checkpoint inhibitor therapy?

1 Answer available

Would you offer adjuvant immunotherapy in a patient with high risk RCC with new/worsening post-op renal dysfunction and CrCl<30?

KEYNOTE-564 required CrCl 30 or above. Not having a baseline/stable CrCl may make it difficult to diagnose or treat IO nephritis.

1 Answer available

Do you recommend a kidney biopsy for patients who develop acute kidney injury after starting sacituzumab?

1 Answer available

How do you manage patients blood pressures while on anti-angiogenic TKIs?

Do you insist on ambulatory/home blood pressures to rule in/out white coat hypertension? Does your practice have a system to log patients' BPs to supp...

1 Answer available

What are your next steps for managing biopsy-proven interstitial nephritis from checkpoint inhibitors in patients who do not have a response to prednisone?

3 Answers available

Do you recommend preloading with IV magnesium to decrease the risk of cisplatin nephrotoxicity?

3 Answers available

How do you manage hyponatremia in patients with renal cell carcinoma on cabozantinib and nivolumab?

2 Answers available

When do you perform a kidney biopsy in a patient with AKI that is thought to be related to an immune checkpoint inhibitor?

Do you wait to monitor response to empiric corticosteroids before pursuing a kidney biopsy?

2 Answers available

Do you recommend retreatment with an immune checkpoint inhibitor in a patient with a history of immune checkpoint inhibitor-related AKI that resolved with holding the immune checkpoint inhibitor and a glucocorticoid taper?

3 Answers available

Papers discussed in this category

Cancer, 2017-06-01

Immune checkpoint inhibitors in challenging populations.

N Engl J Med,

Adjuvant Pembrolizumab after Nephrectomy in Renal-Cell Carcinoma.

Cancers, 2022 May 17

Mechanism and Management of Checkpoint Inhibitor-Related Toxicities in Genitourinary Cancers.

International journal of urology : official journal of the Japanese Urological Association, 2023 Jun 06

Tolerability of immune checkpoint inhibitor doublet for advanced renal cell carcinoma patients with pre-dialysis chronic kidney disease or end-stage renal disease.

Journal for immunotherapy of cancer, 2020 Oct

Immune checkpoint inhibitor associated reactivation of primary membranous nephropathy responsive to rituximab.

Medical Oncology

Onconephrology

Questions discussed in this category

Papers discussed in this category

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