Neurology
Expert perspectives on neurological conditions, stroke management, movement disorders, and neuromuscular disease.
Recent Discussions
What are the main reasons that exercise trials have collectively failed to demonstrate sufficient evidence for disease modification in Parkinson's disease?
This paper by Ruiz et al discusses your question: On Disease Modifying and Neuroprotective Treatments for Parkinson's Disease: Physical Exercise. A big problem with studying exercise in any disease is that patients who can exercise are generally healthier than patients who cannot, so studies compari...
Would you start anticoagulation in a patient with a history of CVA 1 year ago and high risk APL profile who was never started on anticoagulation, but is now presenting for follow up and without recurrent thrombotic events?
This is a difficult question. The details here are important. Therapeutically, you can go either way in my opinion. Were the positive antiphospholipid antibodies checked again later? Did the patient have an infection when the APS labs were first done? Does the patient have diabetes or other CV risk ...
What additional testing besides LAC/APLS, factor V Leiden, prothrombin gene mutation, JAK 2 do you draw for unprovoked cerebral venous sinus thrombosis?
Cerebral venous sinus thromboses (CVST) are often put into the category of "thromboses of unusual sites,"--as opposed to the more common lower extremity thromboses or pulmonary emboli.Provoked causes of CVST include pregnancy or exogenous estrogen use, infection of the head/neck or CNS, head trauma,...
How long can you treat dermatomyositis with IVIG?
Typically, in best-case scenarios, you can treat dermatomyositis with IVIG for 1 year, but some patients require it for 18-24 months, and the minority of patients continue to require it over several years. Some patients may only need it until you achieve improvement, especially in some countries whe...
Do you routinely screen for sleep apnea in patients with acute ischemic stroke?
We at least ask the patient and family about sleep apnea symptoms. In patients who answer positively, or in those who deny symptoms but have obvious risk factors such as obesity, we do make the referral to our sleep clinic.
Which IV medications do you offer for outpatient headache infusions?
Eptinezumab (Vyepti) in a dose of 100 or 300 mg. It is a CGRP antibody marketed for the preventive treatment of episodic or chronic migraine. However, in a randomized, double-blinded, placebo-controlled trial treating patients with 100 mg IV for moderate or severe migraine headache, it met the FDA-d...
Do you utilize muscle MRI to track disease progression in myopathies?
Muscle MRI can be helpful in assessing for active disease/inflammatory myopathy and can help sampling in a more targeted manner when considering a muscle biopsy. Fatty replacement is seen in more advanced cases of myopathy and has been used as a marker of disease progression in non-inflammatory/slow...
How do you manage cranial radiotherapy in the setting of an acute CVA?
Location of the infarct is important to consider, like brainstem or cerebellum or MCA areas apart from functional status. Lesion (infarct) volume (measured on DW-MRI) is an objective surrogate marker for infarct resolution [Gaudinski et al., PMID 18635854]. Either a SPECT or PET/CT scans can be used...
Do you ever use bevacizumab in combination with standard radiation and temozolomide in the first-line setting for patients with glioblastoma?
Two clinical trials (AVAGLIO and RTOG 0825) used bevacizumab (Avastin) along with standard temozolomide and radiation therapy for newly diagnosed glioblastoma. While they did not see improved OS, they did see improved PFS. In an evaluation of AVAGLIO, for those patients who did not go on to receive ...
How do you choose between adjuvant PCV vs temozolomide in high risk oligodendroglioma with IDH mutation and 1p/19q co deletion?
In our practice, we typically offer procarbazine/lomustine (with or without vincristine) to all patients with high risk oligodendroglioma, IDH mutated, 1p/19q codeleted. Temozolomide based on the Stupp regimen is used as an alternative when there are specific concerns for PCV related toxicity or str...