Radiation Oncology
Expert insights on radiation treatment planning, techniques, toxicity management, and multimodal cancer care.
Recent Discussions
How do you approach a patient with avascular necrosis and symptomatic bone met in the region?
In such a patient, I would want know, though not in this order: 1. Tumor type: aggressive v. non-aggressive 2. Does the ortho service think the patient is a surgical candidate for Total Hip Replacement? Post op scheme fractionation 10 or so fractions? If aggressive histo maybe 5 post op fractions. 3...
For large AVMs that cannot meet the V12 dose constraint, how low are you willing to go in terms of single fraction dosing?
We usually use a “volume staging” approach by treating part of the AVM to 18-20 Gy in one fraction (meeting the V12 dose constraint), and return to treat the remaining nidus about 2 years later. Generally most or all of the treated nidus has occluded by then. There will of course be some dose overla...
When do you consider upfront surgery for locally advanced (T4) sinonasal CA?
I usually favor upfront induction chemotherapy for the unresectable cases or if upfront surgery has the risk of unacceptable morbidity. We then evaluate the role of surgery based on histology. For most histologic sub-types of sino-nasal malignancy, we favor primary surgical resection (salivary gland...
What elective areas do you cover for a primary oropharynx SCC isolated to the pharyngeal wall?
In addition, you would also cover the entire retropharyngeal lymph node axis - jugular foramen down to hyoid, both medial/lateral nodes. If either side of neck is N+, can consider IB/V. And, then treat as you would other head and neck - GTV + CTV + PTV to high dose, intermediate risk can be higher ...
Are you concerned about fiducials shifting within the prostate during prostate IMRT?
I think that it is important to consider what type of on-board imaging is being utilized. If it is a CBCT, then there will be additional information that can be interrogated when determining how to adjust shifts. If it is a fiducial match protocol, then I think that it is important to keep abreast o...
When treating a patient definitively for high risk prostate cancer, how would you interpret the interval development of sclerotic bone lesions that appeared during neoadjuvant ADT?
It most likely reflects treated metastatic disease but can be very difficult to prove, as bx yield is low since it has been treated. Would not change management and complete planned treatment. Stampede also showed benefit of local RT for limited bone mets
Would you recommend EBRT/brachythrapy for any patients with stage III- IV uterine ca in light of GOG-258 data?
GOG-258 will certainly change management approach. The recurrence pattern between the two arms (higher distant mets in chemo RT arm and higher locoregional recurrence in chemo alone arm) suggests that sequencing of treatment may also matter. Our current approach is to have chemotherapy first and con...
Would you offer adjuvant radiation therapy for high grade T1 nasal vestibule squamous cell carcinoma with negative margin (5mm) but positive focal perineural invasion?
Yes to the primary site and neck. I likely would have recommended RT rather than surgery at the outset
How long after biopsy is it safe to place rectal spacer when treating a patient definitively for prostate cancer?
Depends on the method of biopsy. Transperineal, think it would be safe to do this immediately. Transrectal biopsy I would be more concerned about infection and would wait 3 days.
Would you recommend nodal irradiation in a patient with breast cancer with a single positive sentinel node and a low Oncotype who does not receive chemotherapy?
Without knowing all the details, this sounds like a patient that may have been eligible for Z11 (early stage patients treated with BCS and SLN bx who were found to have 1-2 positive SLN then randomized to ALND vs no further surgery with all patients receiving at least tangents to breast). There was ...