When do you consider upfront surgery for locally advanced (T4) sinonasal CA?
2 Answers
Mednet Member
Radiation Oncology · UCSD Radiation Oncology
I usually favor upfront induction chemotherapy for the unresectable cases or if upfront surgery has the risk of unacceptable morbidity. We then evaluate the role of surgery based on histology. For most histologic sub-types of sino-nasal malignancy, we favor primary surgical resection (salivary gland...
Mednet Member
Medical Oncology · Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
I guess this is SNUC in which case, surgical R0 resection results in best outcomes. If there is intracranial extension or surgery would involve morbid procedures such as orbital exenteration, I would favor neoadjuvant chemo. There is some data for TPF followed by chemoradiation. If there is a trial ...