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Do you always pursue stroke work up in patients diagnosed with transient global amnesia?

For patients clinically presenting with Transient Global Amnesia and no other focal neurologic deficits, do you always pursue work up to rule out stroke (i.e MRI Brain Wo contrast, vessel imaging)? Would you consider tPA if the patient presents within window for tPA?
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What workup do you do for patients with TGA?

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8 Answers
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Neurology · Stony Brook University School of Medicine
Answered on

I do not routinely recommend imaging or EEG for clinically straight-forward patients with Transient Global Amnesia (TGA), although I suspect I am in the minority. When the diagnosis is in question, or when the symptoms have not resolved, then yes, I would do additional workup, including MRI and EEG....

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Neurology · University of California Los Angeles
Answered on

MRI/MRA with stroke protocol (DWI, ADC) makes sense, even though it is unlikely to be positive. Better safe than sorry!

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Neurology · Bellin Health
Answered on

For straightforward TGA (without atypical features), I do not like routine imaging or an EEG, because it often does not change management. Having said that, >50% of my stroke attendings (n=10) will recommend ordering a fast protocol MRI (which includes DWI and FLAIR) routinely no matter the clinical...

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Neurology · AINeuroCare
Answered on

TGA is analogous to TIA. I would work up the patient as TIA and follow TIA protocols at your local institute.

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Neurology · Presbytarian Hospital
Answered on

As I answered before, other neurologic diseases could present as TGA. Since MRI is now easier to get but still clinically expensive, at least I will do one without contrast. That will depend also upon my level of suspicion.

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Neurology · Zucker School of Medicine at Hofstra/Northwell
Answered on

I am no stroke neurologist, but in my experience in the era of more rapidly available CTH/CTA (+/-CTP), I have skipped MRI especially in the ER presentation. This is for the straightforward TGA case, often a good majority of them are improving already by the time they present. Having a negative CTA ...

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Neurology · Independent Consultant
Answered on · Updated on

I’ve been keeping track, since my residency in 2012, of patients who had a lapse of time and or lapse of memory. The symptoms, in general, were consistent with TGA, typical or atypical, and at baseline when I saw them, 32 patients in total:

  • All had MRI b and EEG;
  • 11 had embolic cortical MCA distrib...

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Neurology · Columbia University
Answered on

Like Dr. @Dr. First Last, I do not recommend neuroimaging or EEG for straightforward classic cases of TGA meeting previously reported diagnostic criteria.

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