Do you avoid triptans in patients on SSRI's due to the potential risk of serotonin syndrome?
Answer from: at Academic Institution
I feel very comfortable using triptans with SSRIs/SNRIs. In 2010, the American Headache Society released a position statement on this very issue:Evans et al., PMID 20618823Their position is that the available evidence does NOT support the claim that triptans should not be used with SSRIs or SNR...
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Answer from: at Academic Institution
Almost never. If someone was on huge doses of one or both drugs I might think about it. For about 25 years or more, I have gotten calls from pharmacies about prescribing the 2 together and I have said thank you, I will think more about it, but I do not believe there is a significant risk of serotoni...
Answer from: at Community Practice
The short answer to this question is, NO. Triptans have very poor CNS penetration and are highly selective in their interaction with serotonin receptors. I am much more concerned about psychiatrists having patients on multiple medications that act on the serotonin system.
Answer from: at Community Practice
I agree with the above and in 25 years of practice and seeing thousands of patients with headaches, I never saw serotonin syndrome.
Answer from: at Academic Institution
There is a warning but I have never experienced serotonin syndrome as a side effect in any of my patients. Most of my adolescent patients are already on SSRIs.
Answer from: at Academic Institution
I agree with the comments, here is another recent article about the topic published by one of my colleagues:Orlova et al., PMID 29482205