Do you feel comfortable using ribociclib in a patient with metastatic ER+/HER2+ breast cancer who has borderline systolic heart failure from previous HER2 based treatment?

My short answer to the question is, yes, I would feel comfortable treating a metastatic breast cancer with ribociclib despite the presence of borderline CHF related to prior anti-HER-2 therapy.

As always, in the treatment of metastatic breast cancer, decisions regarding treatment typically come down...