Do you give radiation concurrently with adjuvant pertuzumab in locally advanced Her2 pos breast cancer?

The most directly relevant data are APHINITY, in which adjuvant RT was given concurrently with HER2-targeting; good cardiac outcomes were seen in that study.

I am in agreement here. Women with lumpectomy on APHINITY were encouraged to get simlutaneous radiation and traztuzumab/pertuzumab; there did not appear to be any increase in cardiac or other side effects over the traztuzumab arm of the trial in these subjects.