Do you often see clinical improvement that is significant enough to de-list patients with CF for transplant after the initiation of CFTR modulator therapy?

Yes, this is actually very common and has led to a dramatic decrease in lung transplants and referrals for persons with CF.

Here is a paper from France that shows this more systematically Burgel et al., PMID 33600738.

There is also a follow-up paper, which I cannot find right now.

Denis Hadjiliaids

https://www.cff.org/medical-professionals/patient-registry

You can download the CF Patient Registry Annual Data Report with this link. On page 71 of the report, the number of individuals receiving a transplant by year is provided. There was a steadily increasing trend (with 2016-19 averaging about 2...