Do you recommend holding tyrosine-kinase inhibitors for extracranial metastases being treated with SBRT?

In general, yes I would recommend holding TKIs during SBRT. Anecdotally from both my own experience and others, there is a small risk of severe pneumonitis in patients on concurrent or recent TKI (much of this with osimertinib which has a reasonably high risk of symptomatic pneumonitis on its own) a...