Topics:
Radiation Oncology • Pediatric Oncology
Do you routinely recommend proton therapy for whole ventricular radiation for intracranial germinoma after chemotherapy?
Do you treat in a response adjusted fashion as per ACNS1123 Stratum 2: 18-24 Gy whole ventricle with 12 Gy boost? Are there any situations where you deviate from this practice?
What are the advantages/disadvantages of the US approach vs. the SIOP GCT II approach?
Answer from: Radiation Oncologist at Academic Institution
The pattern of failure data from SIOP GCT '96 (Calaminus et al., PMID 23460321) and the SFOP-90 experience (Alapetite et al., PMID 20716594) in which patients with localized CNS germinoma were treated with induction chemotherapy followed by focal radiotherapy was predominantly intraventricular. Ther...
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Answer from: Radiation Oncologist at Community Practice
According to the European Concept after complete response to chemotherapy WVI with 24 Gy would be administered; early results seem to confirm effectiveness (NCT01424839 - not yet published). A local boost is required (16 Gy) after WVI in case of an incomplete response to chemotherapy. This is typica...