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Do you routinely treat oligoprogressive metastatic sites with SBRT in patients receiving systemic therapy and otherwise stable disease?

We have been receiving referrals for oligoprogressive SBRT for multiple primary tumors (NSCLC, Colorectal, Renal Cell, etc.) in the setting of diffusely metastatic cancer. Usually these patients are on some form of immunotherapy or other targeted therapy.
2 Answers
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Radiation Oncology · Mayo Clinic, Rochester
Answered on

I am often referred patients who have oligoprogressive disease in the context of widely metastatic disease that is responding to systemic therapy, particularly targeted therapies. These patients have often been on these therapies for at least a year and generally have good performance status. The de...

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Radiation Oncology · Princess Margaret Cancer Centre
Answered on

Would put the patients on trials first if there is one.

If not, I would be more inclined to treat OPD NSCLC vs. other histologies, given the lack of evidence beyond NSCLC. However, I have offered SBRT to patients with cancers other than NSLC after thorough discussions of potential side effects and b...

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