Do you routinely use mannitol to prevent cisplatin-induced nephrotoxicity?

Having treated thousands of patients over the past several decades, we NEVER use mannitol nor do we find any logic for its administration in patients getting appropriate pre-chemo and post cisplatin saline hydration.

Studies on mannitol efficacy in reducing cisplatin-induced nephrotoxicity have reported conflicting results. Mannitol is an osmotic diuretic and has been used in the past for the prevention of cisplatin-induced nephrotoxicity with the rationale that it could reduce the half-life of cisplatin in the ...

I agree. Having treated many patients over the years without mannitol, we have never encountered renal failure. I confer with the others who have posted comments; I would not recommend its use.

I never used mannitol in these patients and only give good hydration.