Do you screen adults in your practice with sickle cell disease for silent cerebral infarcts?

Topics: Pediatric Oncology • Hematology • Sickle Cell • Pediatric Hematology • Benign Hematology • Neurology • Vascular Neurology

The ASH 2020 guidelines have "recommended that adults with HbSS or HbSβ⁰ thalassemia be screened at least once for silent cerebral infarcts even though there is no evidence for secondary prevention of silent cerebral infarcts in the adult age group." Are you doing this in your practice (assuming it was not already done in childhood)?

Answer from: at Academic Institution

The details of the ASH guidelines regarding adults are complex. It was not my practice to screen all patients. More than 50% of adults have silent infarction. Screening requires MRI and this, according to the guidelines, needs careful attention to many details before it is reliable. There are no pro...

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at FibroFighters Foundation
DeBaun et al., PMID 25140956

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