Do you taper glucocorticoids less aggressively when symptoms improve but serologies remain active in a patient with non-renal SLE?

Cautious tapering of glucocorticoids is a good idea in the setting of ongoing serologic activity. However, given there is clinical improvement in symptoms, one can go ahead and proceed with tapering steroids. It is important to recognize that a subset of patients with SLE may have persistent abnorma...

In addition, I would monitor creatinine, urine protein, and albumin very closely.

I would worry more about the degree of immune-mediated activity, but would still move forward with an aggressive steroid taper. I would monitor for an increase in disease activity, i.e., complement and inflammatory markers, closely.