Do you use an SIB schema for salvage post-prostatectomy RT when treating the fossa in ~33-39 fractions and including the pelvic lymph nodes?

Some have adopted 25 fraction regimens with the simultaneous delivery of 62.5 Gy to the operative bed and 45-50 Gy to the regional pelvic lymphatics, in part based on the randomized NRG-GU003 (Buyyounouski et al., PMID 38483412), which should be reporting updated results on efficacy and toxicity lat...

Agree with Dr. @Dr. First Last and the additional discussions about hypofrac that have been addressed elsewhere on MedNet.

I also favor a sequential approach when doing conventional fractionation (32-40 fractions).

To probe what a full SIB approach might look like, you're pushing potentially 150 cGy...