Do you use an SIB schema for salvage post-prostatectomy RT when treating the fossa in ~33-39 fractions and including the pelvic lymph nodes?
Would the low dose per fraction to the nodes be of concern given the low a/b of prostate cancer? Is there any published data for this approach? Should sequential approaches only be used?
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What is your preferred dose/fractionation schema for salvage post-RP RT when treating the fossa with conventional fractionation and including pelvic lymph nodes?
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Mednet MemberInvited Expert
Radiation Oncology
Answered on
Some have adopted 25 fraction regimens with the simultaneous delivery of 62.5 Gy to the operative bed and 45-50 Gy to the regional pelvic lymphatics, in part based on the randomized NRG-GU003 (Buyyounouski et al., PMID 38483412), which should be reporting updated results on efficacy and toxicity lat...
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Mednet MemberInvited Expert
Radiation Oncology · Memorial Sloan Kettering Cancer Center
Answered on
Agree with Dr. @Dr. First Last and the additional discussions about hypofrac that have been addressed elsewhere on MedNet.
I also favor a sequential approach when doing conventional fractionation (32-40 fractions).
To probe what a full SIB approach might look like, you're pushing potentially 150 cGy...
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