Please select the option that best describes you:
Do you use combination therapy for persistent MSSA bacteremia?
If yes, which combination(s)?
Answer from: at Community Practice
I don’t think I’ve ever come across a situation where the problem wasn’t source control…
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Answer from: at Academic Institution
A wide variety of combinations have been used (Chastain et al., PMID 36946576), but there is no solid convincing evidence favoring any single one. In addition, there is strong evidence indicating a clinical (as opposed to, perhaps, a microbiological benefit). I have, however, used cefazolin together...
Answer from: at Community Practice
Routine use of combination therapy for persistent MSSA bacteremia is not supported by current evidence or guidelines, but it may be considered as salvage therapy in refractory cases after source control and infectious diseases consultation.
Randomized clinical trials have not demonstrated imp...
Answer from: at Community Practice
I've done this in a couple of cases when desperate. Excellent comments and references above, including Dr. @Deresinski's mention of the CID 2020 case series.One more single case report to mention: Sakoulas et al., PMID 27572414Cefazolin/Erta likewise successfully cleared persistent MSSA bacteremia a...