How do you typically manage a patient with a single positive blood culture from two sets growing Candida species in a stable patient without prosthetic devices or material?
Answer from: at Academic Institution
Candidemia is defined as the presence of Candida species in the blood, and even a single positive blood culture specimen is considered significant and warrants treatment as candidemia. Initial management should include:
Initiating antifungal therapy with an echinochandin (micafungin, capsofungin,...
Looking for the source would be key to guiding therapy and the need for further workup. Was it an indwelling Foley or a central line? If removed and exchanged, and blood cultures are clear and no concerns for endocarditis, 2 weeks of antifungal therapy would be enough. I would start with echinocandi...
Overwhelmingly depends on clinical circumstances. C albicans is an uncommon but not unheard of contaminant. If otherwise asymptomatic without prosthetic material or long-term IV catheter, I would repeat blood cultures x2 every 3-4 days x 7-10 days and withhold antifungal therapy pending blood cultur...
If hospital onset and prompt therapy are initiated and no visual complaints, I do not think a bedside ophtho exam is required, and on a practical level, it can be difficult to obtain. Recommend outpatient ophtho in the office instead. Curious how much fungal endophthalmitis people have seen. I have ...