Do you use hydroxychloroquine for patients with asymptomatic primary Sjogren syndrome to treat hypergammaglobulinemia without other concerning features?  

I routinely use hydroxychloroquine in a significant proportion of my patients. While the JOQUER trial (Gottenberg et al., PMID 25027140) did not meet its primary endpoint, defined by improvement of the common symptoms of pain, fatigue, and dryness, I think there is a broad consensus among experience...