For a patient with locally current endometrial cancer whose disease had complete radiographic response to carboplatin, Taxol, and pembrolizumab, would you consider adding radiation therapy?

Despite having a complete response to chemoimmunotherapy, I would tend toward adjuvant RT since this was a local recurrence.

We don't have long-term data with chemoimmunotherapy in this locally recurrent setting.

I would add RT, as the goal is still curative and we have not replaced the value of local treatment with systemic alone. Plus, we don't have data on the long-term durability of this complete response.