For an otherwise healthy post-menopausal woman with early stage HR+ BC and persistent AI intolerance, is there an age cutoff above which you would consider avoiding adjuvant tamoxifen therapy?
The patient has an intact uterus and has failed all available AI therapies due to multiple intolerances.
Answer from: Medical Oncologist at Academic Institution
There is no age cut-off based on chronological age. However, physiologic age and comorbid conditions are what I would use. For example, a 72 yo with diabetes, hypertension, and coronary artery disease is likely to die of her underlying conditions and not early stage breast cancer (Ording et al., PMI...
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