For concurrent chemoradiation in head and neck cancers, how important is the timing of weekly radiosensitizing cisplatin early versus late in the week?

Our protocol for concurrent cisplatin-RT demands that the drug will be infused 1-2 hours before RT, usually on Mon. The assumption is that it will allow maximal drug concentration in the cancer cells at the time RT is delivered after chemo on that day, early in the week, while some radiosensitizatio...

I do not know but suspect that it doesn't make much of a difference as long as it is concomitant.

Interesting question, but there have been no trials looking at day of the week for cisplatin infusion. While starting with cisplatin prior to radiation on Monday makes theoretical sense, there are logistic barriers that are not specific to institutions or organizations.

The pharmacokinetics of cispl...

Interesting comment by @Dr. First Last. Back in the late 90's and early 2000's, as I recall, there was a series of articles by Branislav Jeremic discussing the results of cisplatin administered daily at a dose of (if memory serves) 6 mg/m2/day in a variety of settings including H&N cancer, and the r...