For locally advanced rectal cancer, will the recent update of RAPIDO lead you to change your practice when approaching TNT?

We prefer long course chemoradiation followed by consolidation with FOLFOX and non-operative management based on the OPRA trial, which reported 60% versus 40% using this sequence versus initial chemotherapy.

There are a number of subtleties regarding risk factors and their association with competing risks of distant vs locoregional relapse that influence my decision-making regarding short vs long course and in some capacity, sequence of therapies. I do use short course quite frequently (~60% I’d estimat...