For patients with a history of pregnancy loss, do you evaluate for PAI-1 polymorphisms as part of a thrombophilia workup?
If positive, do you anticoagulate for subsequent pregnancies?
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What thrombophilia testing do you perform for recurrent pregnancy loss?
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1 Answer
Mednet MemberInvited Expert
Hematology · BIDMC
Answered on · Updated on
I do not.
The relationship between PAI-1 polymorphisms and thrombosis is complicated, and general guidance suggests against assessing for PAI-1 overexpression as part of a thrombophilia workup. While there is some data to suggest an association between PAI-1 polymorphisms and pregnancy loss, ALIFE2 s...
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