For patients with locally advanced rectal cancer who desire organ preservation and can tolerate fluoropyrimidine but not oxaliplatin, what is the appropriate treatment approach?
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2 Answers
Mednet Member
Medical Oncology · OHSU Knight-Legacy Health Cancer Collaborative
For patients with locally advanced rectal cancer who desire organ preservation and cannot tolerate oxaliplatin, the appropriate treatment approach would be neoadjuvant, long-course radiotherapy combined with fluoropyrimidine-based chemotherapy.
After neoadjuvant treatment, patients are ev...
Mednet Member
Medical Oncology · UH Seidman Cancer Center, Case Western Reserve University
It will depend on the extent of the disease. CRT with 5-FU/LV can achieve organ preservation in appropriately selected patients (Habr-Gama et al., PMID 30870223). I would like to add systemic chemo if bulky disease (T4 tumors, N2 disease), EMVI, etc. However, patients should be counseled that NOM is...