For patients with SLE, is there an ANC level for which you would hold or adjust hydroxychloroquine in an asymptomatic patient?

Leukopenia most often as lymphocytopenia, of course, is not unusual in lupus. Total WBC less than 4000 is an ACR classification criteria for the disease as is ALC less than 1500 on two occasions. SLICC disease classification requires ALC less than 1000. Total WBC < 3000 generates SLEDAI points. On t...

While one can never completely exclude any drug as a potential cause of neutropenia, in 36 years of practice managing SLE patients, I have never encountered a bona fide case of HCQ-induced neutropenia (i.e. resolution with holding the drug and recurrence following re-introduction). As such, when neu...