Given the results of ESOPEC from ASCO 2024, for which patients with resectable esophageal adenocarcinoma would you favor neoadjuvant chemoradiation?

It is a great question and something that I think all of us are still wrestling to digest and readjust our treatment algorithm for patients with esophageal cancer. First, I think Dr. @Dr. First Last did an outstanding job putting ESOPEC in context in the esophageal cancer treatment landscape. In add...

I do think we have to prioritize systemic therapy with at least 2-4 cycles of FOLFOX or FLOT (distant mets kill patients). If the consensus is that R0 resection is not achievable, then following that with CRT would be reasonable to improve locoregional control. Enrolling in induction chemo-->nCRT tr...

Dr. @Dr. First Last has a great X thread summarizing ESOPEC in the context of past trials with esophageal adenocarcinoma! Check it out.