Given the significant risk of recurrence after chemoradiation for locally advanced anal carcinoma, should resection be considered (with or without neoadjuvant treatment) in select cases?

Interesting question. As a practical matter, many of the tumors that start out unresectable get replaced with dense fibrosis--and, therefore remain major surgical challenges even if there's residual cancer within the fibrosis.

Many people argue that, since anal cancer can be slow to manifest complet...