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How do the results of BRAF testing change your management of colon cancer?

Has the utility of BRAF in CRC expanded beyond guiding prognosis? Is there a role in non-metastatic CRC?
2 Answers
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Mednet MemberInvited Expert
Medical Oncology · Rutgers Cancer Institute of New Jersey
Answered on

BRAF testing is essential for metastatic colon Cancer. The patients with BRAF mutated cancers tend to be younger, have right sided tumors, and have extensive disease. Their survival is about half of those with wild type BRAF. It is essential these patients receive FOLFOXIRI and bevacizumab therapy f...

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Mednet Member
Mednet Member
Medical Oncology · University of Minnesota Medical Center
Answered on

This is a very interesting question, the answer to which is likely to change over the next few years. In the past two years, the panel of suggested biomarkers for metastatic colorectal cancers has expanded to include more variants of the KRAS and NRAS oncogenes. This approach is called “All-Ras test...

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