How do you approach a patient with recurrent endometrial cancer within the field of prior primary radiation who is not a surgical or cytotoxic chemotherapy candidate?

There are several things to consider here.

Assuming that there is truly no potential for surgery or cytotoxic chemotherapy then the remaining options are: targeted therapy, hormonal therapy, discussing with radiation oncology any role for additional radiation, or best supportive care.

First, though, I would want to truly understand what is the goal of treatment. For example, if the patient is highly symptomatic and the only goal is symptom control, I would approach the case differently than someon...