How do you approach a positive Quantiferon/PPD test result in a patient for whom testing is sent without a clinical indication and who does not have a risk factor for TB exposure nor TB reactivation?

If a test for TB infection such as a Quantiferon or PPD is done without TB exposure risk factor or clincial indication and is positive, a chest X-ray and good history for symptom assessment and exam should be done. I will assess to see if there is an increased risk of developing TB such as an immuno...

Pre-test probability is key in TB/LTBI. T-Spot has been a good tiebreaker for me, but I’ve used it pretty much exclusively in situations of an indeterminate QFT. Again, pre-test probability. If still uncertain/unclear and risk of reactivation from, say, use of immunosuppressive medications, I try to...

If conversion happens or risk factors are present then treat.