How do you approach an isolated metastasis to left supraclavicular node in rectal cancer treated with TNT with FOLFOX regimen followed by long course radiation?

MSI stable, NGS without targetable mutation. Would you do FOLFIRI or FOLFIRINOX followed by radiation to the lymph node? Would surgery be an option later on if no metastases?

Answer from: Medical Oncologist at Community Practice

Thanks for the question! The answer depends on several factors. How soon was the recurrence? Does the patient have neuropathy? How is the performance status of the patient? I see no action in NGS, but what about RAS/RAF status?

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How do you approach an isolated metastasis to left supraclavicular node in rectal cancer treated with TNT with FOLFOX regimen followed by long course radiation?

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