How do you approach an isolated T-cell gene arrangement found in the setting of persistent hypereosinophilia?

Topics: Medical Oncology • Hematology • Benign Hematology • T-Cell Lymphoma • Eosinophilia

If all work-up including peripheral flow, bone marrow biopsy, PET-CT returns negative, what additional management (if any) would be recommended?

Answer from: at Community Practice

The lymphocyte variant hypereosinophilic syndrome (L-HES) is a rare form of reactive eosinophilic driven by clonal, phenotypically aberrant T-lymphocytes that secrete IL-5 and other eosinophilopoeitic cytokines. Diagnosis is based primarily on immunophenotyping (flow cytometry) of peripheral blood. ...

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at Kaiser Permanente, Los Angeles Med Center
Thank you for the thoughtful response and referenc...

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