How do you approach cisplatin dosing for locally advanced head and neck SCC—specifically, is weekly 40 mg/m² considered equivalent to high-dose 100 mg/m² q3wk in HPV-positive and HPV-negative patients?  

Weekly cisplatin 40 mg/m² is not yet considered equivalent to high-dose cisplatin 100 mg/m² every three weeks, and high-dose cisplatin remains the preferred regimen for both HPV-positive and HPV-negative locally advanced head and neck squamous cell carcinoma. However, weekly cisplatin is an accept...